Diethylamine → benzyl 4-(N,N-diethylamino)butanoate
반응식
Br[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:6].[CH2:15]([NH:17][CH2:18][CH3:19])[CH3:16]>ClCCl>[CH2:15]([N:17]([CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:6])[CH2:18][CH3:19])[CH3:16]참가 물질
4
실험 절차
A mixture of benzyl 4-bromobutanoate (58.6 diethylamine (58.3 g) and dichloromethane (1000 ml) was stirred under reflux for 14 hours. The reaction mixture was washed with water and dried over magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was subjected to column chromatography on silica gel. The fractions eluted with ethyl acetate gave benzyl 4-(N,N-diethylamino)butanoate (33.8 g, 60%).
후처리
- temperatureunder reflux for 14 hours
- washThe reaction mixture was washed with water
- dry with materialdried over magnesium sulfate
- customthe solvent was evaporated under reduced pressure
- washThe fractions eluted with ethyl acetate
출처 및 근거
- ORD 기록
- ord-5a0cea2b15534838b31d8da8b7eb66e2
- 출처 데이터셋
- uspto-grants-1997_07
- 특허 번호
- US05650410
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