p-Toluenesulfonic acid monohydrate → 2-benzyloxymethyl-propane-1,3-diol

HRID 266229노트

반응식

HRID 266229 반응식
[CH2:1]([O:8][CH2:9][CH:10]1[CH2:15][O:14]C(C)(C)[O:12][CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[CH2:1]([O:8][CH2:9][CH:10]([CH2:15][OH:14])[CH2:11][OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 232952655-((Benzyloxy)methyl)-2,2-dimethyl-1,3-dioxane

생성물 1

HCID 102417822-benzyloxymethyl-propane-1,3-diol수율 80%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 5-benzyloxymethyl-2,2-dimethyl-1,3-dioxane (3.40 g, 14.4 mmol) and a few crystals of p-toluenesulfonic acid monohydrate in 100 mL of methanol was stirred at room temperature for 20 h. The methanol was removed in vacuo and the residual oil purified by column chromatography on silica gel (ethyl acetate) to give 2.25 g (80%) of 2-benzyloxymethyl-1,3-propanediol as a colorless, clear liquid.

후처리

  1. customThe methanol was removed in vacuo
  2. customthe residual oil purified by column chromatography on silica gel (ethyl acetate)

출처 및 근거

ORD 기록
ord-b4eb1bc56a7a42b4a16ddcb87fd90dbc
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05650510

반응 노트

불러오는 중…