Diisopropyl Ether → (2Z)-2-[2-(dimethylaminomethylideneamino)-1,3-thiazol-4-yl]-2-methoxyiminoacetyl chloride;hydrochloride

참여 물질

역할	이름	HCID	투입량
반응물	Diisopropyl Ether	HCID 7914	—
반응물	(alphaZ)-2-Amino-alpha-(methoxyimino)-4-thiazoleacetic acid	HCID 5486924	—
반응물	Dimethylaminochloromethyleneammonium chloride	HCID 86750850	—
용매	Tetrahydrofuran	HCID 8028	—
생성물	(2Z)-2-[2-(dimethylaminomethylideneamino)-1,3-thiazol-4-yl]-2-methoxyiminoacetyl chloride;hydrochloride	HCID 140382097	96.9%

반응 조건

온도	-12 °C

반응 단계

Dimethylaminochloromethyleneammonium chloride (1.54 g, 12.0 mmol) was dissolved in 7 ml of tetrahydrofuran, followed by cooling to -12° C. Added to the solution were 1.10 g (5.5 mmol) of (Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetic acid and the resulting mixture was stirred for 40 minutes. Isopropyl ether (16 ml) was added to the reaction mixture, followed by stirring for 40 minutes. Deposited crystals were collected under a nitrogen gas stream, collected by filtration and then dried, whereby 1.65 g of the title compound were obtained (yield: 96.9%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US05650518
출처 데이터셋	uspto-grants-1997_07
ORD ID	ord-a2d5756d3e9f45d38aee089027d73d8e
출처 메모	uspto-grants-1997_07