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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 266279생성일: 2026년 10월 26일

4-Iodobenzenesulfonyl chloride → 3-(Tetrahydropyran-2-yloxy)propanamide

https://huagongshe.com/reaction/266279

반응식

참여 물질

역할이름HCID투입량
반응물4-Iodobenzenesulfonyl chlorideHCID 7399—
반응물(RS)-2-(benzyloxycarbonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy)propanamideHCID 19032873—
촉매PalladiumHCID 23938—
생성물3-(Tetrahydropyran-2-yloxy)propanamideHCID 20393361307.7%

반응 단계

The procedure described in Example 15 was repeated, except that (RS)-2-(benzyloxycarbonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy)propanamide (1.0 g) was hydrogenolyzed in the presence of 10% Pd-C, and then, reacted with 4-iodobenzenesulfonyl chloride (1.31 g) to obtain (RS)-N-(4-(ethoxycarbonyl-methyl)phenyl)-2-(4-iodobenzenesulfonylamino)-N-(3-(tetrahydropyran-2-yloxy)propanamide (1.10 g).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US05650428
출처 데이터셋uspto-grants-1997_07
ORD IDord-17675e42e92f48978a6ebe92b16e83d1
출처 메모uspto-grants-1997_07