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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 266280생성일: 2026년 10월 26일

4-Toluenesulfonyl chloride → (RS)-N-(4-(ethoxycarbonylmethyl)phenyl)-2-(4-methylbenzenesulfonylamino)-3-(tetrahydropyran-2-yloxy)propanamide

https://huagongshe.com/reaction/266280

반응식

참여 물질

역할이름HCID투입량
반응물4-Toluenesulfonyl chlorideHCID 7397—
반응물(RS)-2-(benzyloxycarbonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy)propanamideHCID 19032873—
촉매PalladiumHCID 23938—
생성물(RS)-N-(4-(ethoxycarbonylmethyl)phenyl)-2-(4-methylbenzenesulfonylamino)-3-(tetrahydropyran-2-yloxy)propanamideHCID 1903270051.9%

반응 단계

The procedure described in Example 15 was repeated, except that (RS)-2-(benzyloxycarbonylamino)-N-(4-(ethoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy) propanamide (1.0 g) was hydrogenolyzed in the presence of 10% Pd-C, and then, reacted with 4-methylbenzenesulfonyl chloride (778 mg) to obtain (RS)-N-(4-(ethoxycarbonylmethyl)phenyl)-2-(4-methylbenzenesulfonylamino)-3-(tetrahydropyran-2-yloxy)propanamide (540 mg).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US05650428
출처 데이터셋uspto-grants-1997_07
ORD IDord-0f0084f422da4da4b2e2f2f9faac6f6f
출처 메모uspto-grants-1997_07