Water ethanol → 2-(1-Phenyltetrazol-5-yl)thiomethyl-4-isopropyl-5,6-dimethoxy-saccharin

HRID 266471

반응식

HRID 266471 반응식
Cl[CH2:2][N:3]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][C:9]([O:20][CH3:21])=[C:10]([O:18][CH3:19])[C:11]=2[CH:15]([CH3:17])[CH3:16])[S:4]1(=[O:6])=[O:5].[Na].[C:23]1([N:29]2[C:33]([SH:34])=[N:32][N:31]=[N:30]2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.C(O)C.O>CN(C)C=O>[C:23]1([N:29]2[C:33]([S:34][CH2:2][N:3]3[C:13](=[O:14])[C:12]4[C:7](=[CH:8][C:9]([O:20][CH3:21])=[C:10]([O:18][CH3:19])[C:11]=4[CH:15]([CH3:17])[CH3:16])[S:4]3(=[O:6])=[O:5])=[N:32][N:31]=[N:30]2)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

참가 물질

5

반응물 3

HCID 19096565Water ethanolHCID 700449542-Chloromethyl-4-isopropyl-5,6-dimethoxysaccharinHCID 178527989HCID 178527989, 화합물

생성물 1

HCID 443413782-(1-Phenyltetrazol-5-yl)thiomethyl-4-isopropyl-5,6-dimethoxy-saccharin수율 51%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

By the method of Example 44 condensation of 2-chloromethyl-4-isopropyl-5,6-dimethoxysaccharin (1.46 g) and 1-phenyltetrazol-5-thiol sodium salt (0.92 g) in dimethylformamide (5 mL) and recrystallization of the product from ethanol-water afforded 2-(1-phenyltetrazol-5-yl)thiomethyl-4-isopropyl-5,6-dimethoxy-saccharin, 1.05 g, 51% yield, mp 69°-71° C.

출처 및 근거

ORD 기록
ord-e185b931be7a4eaeafe033a24efcddd3
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05650422

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