참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Ethanethiol | HCID 6343 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 반응물 | 4-Isopropyl-6-methoxysaccharin | HCID 10147362 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 4-Isopropyl-6-hydroxysaccharin | HCID 10037346 | 97% |
반응 단계
Ethanethiol (43.9 g) was added with stirring to a suspension of aluminum chloride (62.74 g) in chloroform (500 mL) at 0° C. To the resulting solution was added a solution of 4-isopropyl-6-methoxysaccharin (20.0 g) in chloroform (550 mL) during 30 minutes. The resulting solution was warmed to and maintained at 60° C. for 3-4 hours, then poured into ice-water acidified with hydrochloric acid. The resulting solid was collected by filtration, washed with water and dried affording 4-isopropyl-6-hydroxysaccharin, 18.4 g., 97% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05650422 |
|---|
| 출처 데이터셋 | uspto-grants-1997_07 |
|---|
| ORD ID | ord-306bf5c300b14710a29032a6cc846099 |
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| 출처 메모 | uspto-grants-1997_07 |
|---|
