2'-Hydroxyacetophenone → 3-Formylchromone

HRID 26658

반응식

HRID 26658 반응식
[C:1](=[O:3])=O.[CH3:4]C(C)=O.[OH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15](=[O:17])[CH3:16]>CN(C)C=O>[O:17]=[C:15]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[O:8][CH:4]=[C:16]1[CH:1]=[O:3]

참가 물질

4

반응물 2

HCID 83752'-HydroxyacetophenoneHCID 18522661Acetone cardice

생성물 1

HCID 871123-Formylchromone

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In 80 volume parts of dimethylformamide are dissolved 25 parts of orthohydroxyacetophenone and, while the solution is externally cooled to about -20° C. with dry ice-acetone, 80 volume parts of tetrachloropyrophosphoric acid are added dropwise to the solution. The resulting mixture is stirred at room temperature for 13 hours. Then, the reaction mixture is poured into ice water and the resulting crystals are recovered by filtration, washed with water and ethanol and finally recrystallized from acetone. The procedure yields of 4-oxo-4H-1-benzopyran-3-carboxaldehyde as colorless crystals melting at 152°-153° C.

후처리

  1. additionare added dropwise to the solution
  2. filtrationthe resulting crystals are recovered by filtration
  3. washwashed with water and ethanol
  4. customfinally recrystallized from acetone

출처 및 근거

ORD 기록
ord-96922e08165340108b55feb1592c051d
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04151180

연결된 노트

불러오는 중…