1-Bromo-2-Chloroethane → 1-(2-Chloroethyl)-3-isopropenyl-2(3H)-benzimidazolone

HRID 266692노트

반응식

HRID 266692 반응식
Br[CH2:2][CH2:3][Cl:4].C(=O)([O-])[O-].[K+].[K+].[C:11]([N:14]1[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[NH:16][C:15]1=[O:23])([CH3:13])=[CH2:12]>CN(C)C=O>[Cl:4][CH2:3][CH2:2][N:16]1[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[N:14]([C:11]([CH3:13])=[CH2:12])[C:15]1=[O:23]

참가 물질

5

반응물 3

HCID 78491-Bromo-2-ChloroethaneHCID 11430Potassium CarbonateHCID 1002781,3-Dihydro-1-(1-methylvinyl)-2H-benzimidazol-2-one

생성물 1

HCID 107050051-(2-Chloroethyl)-3-isopropenyl-2(3H)-benzimidazolone

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

200 mmol of 1-bromo-2-chloroethane and 55 mmol of potassium carbonate are added to 50 mmol of 1-isopropenyl-2(3H)-benzimidazolone in 150 ml of dimethylformamide. The whole mixture is kept stirring for 48 hours. It is then poured into ice-cold water and extracted with dichloromethane. The organic phases are washed with water, dried and evaporated. The residue is then taken up in ether. The ether phase is washed with 2N potassium hydroxide and then with water, dried and evaporated and leads to the expected product.

후처리

  1. additionIt is then poured into ice-cold water
  2. extractionextracted with dichloromethane
  3. washThe organic phases are washed with water
  4. customdried
  5. customevaporated
  6. washThe ether phase is washed with 2N potassium hydroxide
  7. dry with materialwith water, dried
  8. customevaporated

출처 및 근거

ORD 기록
ord-9daaa0aec22543028ba83644f283bc2b
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05652246

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