참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethylene Oxide | HCID 6354 | — |
| 반응물 | 4-(N-Propionylaniline)piperidine | HCID 259381 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 1-(2-Hydroxyethyl)-4-(N-propionylanilino)piperidine | HCID 10850080 | — |
반응 단계
A solution, cooled to 15° C., containing 100 mmol of ethylene oxide in toluene is added slowly to 100 mmol of 4-(N-propionylanilino)piperidine in solution in 100 ml of anhydrous methanol cooled to 15° C. After returning to room temperature and removal of the azeotrope formed by distillation, the expected product is obtained after evaporation to dryness.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05652246 |
|---|
| 출처 데이터셋 | uspto-grants-1997_07 |
|---|
| ORD ID | ord-0cf41979ba5f46fc9d1a0f479f4905b6 |
|---|
| 출처 메모 | uspto-grants-1997_07 |
|---|
