Methoxyacetyl chloride → HCID 10597512, 화합물

HRID 266699노트

반응식

HRID 266699 반응식
[CH3:1][O:2][CH2:3][C:4](Cl)=[O:5].[CH2:7]([N:14]1[CH2:19][CH2:18][CH:17]([NH:20][C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([Cl:28])[CH:22]=2)[CH2:16][CH2:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>O1CCCC1>[CH2:7]([N:14]1[CH2:19][CH2:18][CH:17]([N:20]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([Cl:28])[CH:22]=2)[C:4](=[O:5])[CH2:3][O:2][CH3:1])[CH2:16][CH2:15]1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

참가 물질

4

반응물 2

HCID 96623Methoxyacetyl chlorideHCID 10854237115661-42-2

생성물 1

HCID 10597512HCID 10597512, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

12 mmol of methoxyacetyl chloride are added to 12 mmol of 1-benzyl-4-[(3,4-dichlorophenyl)amino]piperidine obtained in the preceding stage in 50 ml of anhydrous tetrahydrofuran (THF). The mixture is brought to reflux for 3 hours. After cooling, the expected product is obtained by filtering the precipitate, which is washed with THF and dried.

후처리

  1. temperatureto reflux for 3 hours
  2. temperatureAfter cooling

출처 및 근거

ORD 기록
ord-95c02b56a56c495b90db904c696b3a34
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05652246

반응 노트

불러오는 중…