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2-Nitroimidazole → (S)-(+)-alpha-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

HRID 266716
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HRID 266716 반응식
[N+:1]([C:4]1[NH:5][CH:6]=[CH:7][N:8]=1)([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].[CH2:15]([C@H:17]1[O:19][CH2:18]1)[Cl:16]>>[Cl:16][CH2:15][C@@H:17]([OH:19])[CH2:18][N:5]1[CH:6]=[CH:7][N:8]=[C:4]1[N+:1]([O-:3])=[O:2]
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참가 물질

4

반응물 3

HCID 107012-NitroimidazoleHCID 11430Potassium CarbonateHCID 149428(+)-Epichlorohydrin

생성물 1

HCID 11052772(S)-(+)-alpha-(chloromethyl)-2-nitro-1H-imidazole-1-ethanol

실험 절차

Alternatively, a mixture of 2-nitroimidazole, anhydrous potassium carbonate, and (S)-(+)-epichlorohydrin is refluxed for 10 minutes then filtered while hot. The filtrate is concentrated and cooled to give a solid. Crystallization from ethanol and further processing gives the product.

후처리

  1. temperatureis refluxed for 10 minutes
  2. filtrationthen filtered while hot
  3. concentrationThe filtrate is concentrated
  4. temperaturecooled
  5. customto give a solid
  6. customCrystallization from ethanol and further processing
  7. customgives the product

출처 및 근거

ORD 기록
ord-8b9f44a2c47945cba8d44e8530187c1a
출처 데이터셋
uspto-grants-1997_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05652255

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