1-Fluoro-4-nitronaphthalene → 4-Fluoronaphthalen-1-amine

4-Fluoro-1-nitro-naphthalene (1 g) was dissolved in EtOAc (20 mL) and placed into a hydrogenating flask containing Palladium on activated charcoal (10%, 0.3 g). The reaction mixture was hydrogenated at 50 psi for 5 hr. During the reaction, the pressure of the hydrogen dropped due to the consuming of the hydrogen, and it was brought back to 50 psi a few times. Finally, the reaction stopped when all the starting material was used. The resulting solution was filtered through a pad of celite and washed with EtOAc (20 mL). The clear filtrate was concentrated and dried under vacuum to yield 4-Fluoro-1-aminonaphthalene.

1. customplaced into a hydrogenating flask
2. customDuring the reaction
3. customthe pressure of the hydrogen dropped due to the consuming of the hydrogen, and it
4. filtrationThe resulting solution was filtered through a pad of celite
5. washwashed with EtOAc (20 mL)
6. concentrationThe clear filtrate was concentrated
7. customdried under vacuum

ORD 기록

ord-3487040c7d894b0e9df3b1dbab112100

출처 데이터셋

uspto-grants-1997_07

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US05652269