Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroacetyl chloride → 4-Chloroacetamido-3-hydroxypyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroacetyl chloride | HCID 6577 | — |
| 반응물 | 4-Amino-3-hydroxypyridine | HCID 2762419 | — |
| 생성물 | 4-Chloroacetamido-3-hydroxypyridine | HCID 19031663 | — |
반응 단계
A solution of 4-amino-3-hydroxypyridine (7 g, 0.06 mol) and chloroacetyl chloride (50 ml) was refluxed for 2 hours, cooled and the excess solvent was removed by vacuum distillation. The crude material was dissolved in water, neutralized with Na2CO3 and the solid precipitated filtered and air dried to give the desired product, m.p. 155°-158° C. The structural assignment was supported by the proton NMR spectrum.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05652363 |
| 출처 데이터셋 | uspto-grants-1997_07 |
| ORD ID | ord-0e717692545847bf99de662dd998060e |
| 출처 메모 | uspto-grants-1997_07 |