2-Chloro-3-nitropyridine → 2-Methoxy-3-nitropyridine

HRID 266917

반응식

HRID 266917 반응식
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:11][O-:12].[Na+]>CO>[CH3:11][O:12][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 796132-Chloro-3-nitropyridineHCID 10942334Sodium Methoxide

생성물 1

HCID 2532192-Methoxy-3-nitropyridine수율 75.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-Chloro-3-nitropyridine (25 g, 0.157 mol) was suspended in methanol (300 ml) and sodium methoxide (17 g, 0.315 mol) was added. The mixture was refluxed for 2 hr and part of the solvent removed under reduced pressure. The reaction mixture was diluted with water (1 litre) and the precipitate collected by filtration. The white solid obtained was washed with more water and dried under vacuum to give the title compound (18.2 g, 75%). 1H NMR (CDCl3): 8.42 (dd, J=5, 2 Hz, 1H); 8.28 (dd, J=8, 2 Hz, 1H); 7.06 (dd, J=8, 5 Hz, 1H); 4.13 (s, 3H)

후처리

  1. temperatureThe mixture was refluxed for 2 hr
  2. custompart of the solvent removed under reduced pressure
  3. additionThe reaction mixture was diluted with water (1 litre)
  4. filtrationthe precipitate collected by filtration
  5. customThe white solid obtained
  6. washwas washed with more water
  7. customdried under vacuum

출처 및 근거

ORD 기록
ord-686066c2b0da44208fe1b4661a3551e5
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05652363

연결된 노트

불러오는 중…