2-Methoxy-3-nitropyridine → 3-Amino-2-methoxypyridine

HRID 266918

반응식

HRID 266918 반응식
[CH3:1][O:2][C:3]1[C:8]([N+:9]([O-])=O)=[CH:7][CH:6]=[CH:5][N:4]=1>C(O)C.[Pd]>[CH3:1][O:2][C:3]1[C:8]([NH2:9])=[CH:7][CH:6]=[CH:5][N:4]=1

참가 물질

4

반응물 1

HCID 2532192-Methoxy-3-nitropyridine

생성물 1

HCID 27374883-Amino-2-methoxypyridine수율 112%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of the compound of Example 12 (17.12 g, 0.11 mol) in ethanol (180 mL) in a Parr bottle, was added 4% Pd/C (3.43 g). The bottle was sealed, purged with nitrogen and was pressurized (5 psi) with hydrogen. After stirring at room temperature for 2 hr, the reaction vessel was vented, purged with nitrogen and filtered. The clear filtrate was concentrated to give the title compound (15.3 g, 90%). 1H NMR (CDCl3): 7.58 (dd, J=5, 2 Hz, 1H); 6.87 (dd, J=8, 2 Hz, 1H); 6.72 (dd, J=8, 5 Hz, 1H); 3.98 (s, 3H).

후처리

  1. customThe bottle was sealed
  2. custompurged with nitrogen
  3. custompurged with nitrogen
  4. filtrationfiltered
  5. concentrationThe clear filtrate was concentrated

출처 및 근거

ORD 기록
ord-2fc07f81f427453c919067679c441c9b
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05652363

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