Ethyl bromoacetate → HCID 178472639, 화합물

HRID 26700

반응식

HRID 26700 반응식
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[CH:3]1.[Br:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]>CCOCC>[Br-:11].[CH2:16]([O:15][C:13]([CH2:12][N+:4]1[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:2]([CH3:1])[CH:3]=1)=[O:14])[CH3:17]

참가 물질

4

반응물 2

HCID 7748Ethyl bromoacetateHCID 958901H-Benzimidazole, 1-methyl-

생성물 1

HCID 178472639HCID 178472639, 화합물수율 62%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

The 1-methyl-benzimidazole of Step A was dissolved in ether and 1.4 equivalents of ethyl bromoacetate were added thereto. The ether solution was allowed to stand for several days and the crystals formed were recovered for a 62% yield of 1-ethoxycarbonylmethyl-3-methyl-benzimidazolium bromide. After crystallization from an ethyl acetate-methanol mixture, the product melted at 160°-161° C.

후처리

  1. waitto stand for several days
  2. customthe crystals formed

출처 및 근거

ORD 기록
ord-1304c5c6f0684e9e96e83281b74b04e6
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04151280

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