Benzenamine, 2-chloro-5-(trifluoromethyl)- → N-(2,2-dicyanovinyl)-2-chloro-5-trifluoromethylaniline

HRID 26707

반응식

HRID 26707 반응식
[Cl:1][C:2]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][C:3]=1[NH2:4].C(O[CH:16]=[C:17]([C:20]#[N:21])[C:18]#[N:19])C>C(O)C>[C:18]([C:17]([C:20]#[N:21])=[CH:16][NH:4][C:3]1[CH:5]=[C:6]([C:9]([F:10])([F:11])[F:12])[CH:7]=[CH:8][C:2]=1[Cl:1])#[N:19]

참가 물질

4

반응물 2

HCID 8475Benzenamine, 2-chloro-5-(trifluoromethyl)-HCID 671522-(Ethoxymethylene)propanedinitrile

생성물 1

HCID 21322397N-(2,2-dicyanovinyl)-2-chloro-5-trifluoromethylaniline수율 70%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

19.6 Parts of 2-chloro-5-trifluoromethyl-aniline and 12.2 parts of ethoxymethylenemalononitrile are dissolved in 125 parts of ethanol and the mixture is refluxed for 48 hours. After cooling, the precipitated product is collected by filtration and washed with ethanol. Recrystallisation from ethanol affords the above product with a melting point of 166°-169° C. and in a 70% yield.

후처리

  1. temperaturethe mixture is refluxed for 48 hours
  2. temperatureAfter cooling
  3. filtrationthe precipitated product is collected by filtration
  4. washwashed with ethanol
  5. customRecrystallisation from ethanol
  6. customaffords the above product with a melting point of 166°-169° C.

출처 및 근거

ORD 기록
ord-bc92207860594f63ba30a4e98edc8c79
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04151298

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