참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 6-Nitro-3-phenylacetamidobenzoic acid | HCID 193864 | — |
| 반응물 | Penicillin V Potassium | HCID 23676814 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 6-Aminopenicillanic acid | HCID 11082 | 86.1% |
반응 단계
290 g of carrier-bound penicillinacylase according to Example 4, having an enzymatic activity of 2,803 U (NIPAB test) and 138 g of potassium penicillin V are added to 2,000 ml of water and stirred for 9 hours at 38°C. The pH value is kept constant at 7.8 by continuous addition of triethylamine. The mixture is worked up as described in Example 1. Yields of 6-APA 64.3 g (86.1% of theory); purity 97.4%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US03941756 |
|---|
| 출처 데이터셋 | uspto-grants-1976_03 |
|---|
| ORD ID | ord-b637f9b0888d47a1a842be6a33c686f8 |
|---|
| 출처 메모 | uspto-grants-1976_03 |
|---|
