27409-41-2 → 3-Oxocholestane

HRID 267245노트

반응식

HRID 267245 반응식
[OH:1][CH:2]1[CH2:26][CH2:25][C@@:24]2([CH3:27])[CH:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:23]2[CH2:22][CH2:21][C@@:20]2([CH3:28])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C@H:12]([CH3:19])[CH2:13][CH2:14][CH2:15][CH:16]([CH3:18])[CH3:17])[CH2:3]1>[Si]([O-])([O-])([O-])[O-].[Ag+].[Ag+].[Ag+].[Ag+].C(OCC)(=O)C>[CH3:18][CH:16]([CH2:15][CH2:14][CH2:13][C@H:12]([C@@H:11]1[C@:20]2([CH3:28])[C@H:8]([C@H:7]3[C@H:23]([CH2:22][CH2:21]2)[C@:24]2([CH3:27])[CH:4]([CH2:3][C:2](=[O:1])[CH2:26][CH2:25]2)[CH2:5][CH2:6]3)[CH2:9][CH2:10]1)[CH3:19])[CH3:17]

참가 물질

4

반응물 1

HCID 1099274827409-41-2

생성물 1

HCID 108835733-Oxocholestane

시약·촉매·용매 2

HCID 86733097HCID 86733097, 화합물촉매2회HCID 8857Ethyl Acetate용매

실험 절차

388.6 Mg of 3-hydroxy-cholestane, 500 mg of silver silicate and 30 ml of ethyl acetate were added to the flask of Example II and the reaction mixture was refluxed for 10 hours. Another 50 mg of silver silicate were added thereto and reflux was continued for 5 hours. The mixture was then filtered and the filtrate was concentrated to dryness. The residue was dissolved in ether and the ether was distilled off under reduced pressure to obtain 383 mg of cholestane-3-one melting at 115°C, then 128°C.

후처리

  1. temperaturethe reaction mixture was refluxed for 10 hours
  2. temperaturereflux
  3. filtrationThe mixture was then filtered
  4. concentrationthe filtrate was concentrated to dryness
  5. dissolutionThe residue was dissolved in ether
  6. distillationthe ether was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-4fbb10febead4223a6e2c96361c6023a
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03941811

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