Allyl bromide → N-(4-chlorophenyl)-1-(2-propenyl)-4-piperidinamine

HRID 26749노트

반응식

HRID 26749 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1.C(N(CC)CC)C.Br[CH2:23][CH:24]=[CH2:25]>C1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:25][CH:24]=[CH2:23])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 7841Allyl bromideHCID 8471TriethylamineHCID 7183033N-(4-chlorophenyl)piperidin-4-amine

생성물 1

HCID 23339007N-(4-chlorophenyl)-1-(2-propenyl)-4-piperidinamine

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

To a stirred mixture of 15 parts of N-(4-chlorophenyl)-4-piperidinamine, 12 parts of N,N-diethylethanamine in 130 parts of benzene is added dropwise a solution of 10.3 parts of 3-bromo-1-propene in 70 parts of benzene. Upon completion, the whole is stirred first for 20h.30 at room temperature and further for 40 minutes at reflux. The reaction mixture is cooled, filtered and the filtrate is evaporated. The residue is taken up in 1,1'-oxybisethane and treated with activated charcoal. The latter is filtered off and the 1,1'-oxybisethane is evaporated again, yielding 2.9 parts of N-(4-chlorophenyl)-1-(2-propenyl)-4-piperidinamine; mp. 90° C.

후처리

  1. temperatureat reflux
  2. temperatureThe reaction mixture is cooled
  3. filtrationfiltered
  4. customthe filtrate is evaporated
  5. additiontreated with activated charcoal
  6. filtrationThe latter is filtered off
  7. customthe 1,1'-oxybisethane is evaporated again

출처 및 근거

ORD 기록
ord-d72e82e1e56f4241b4c164d2fa7acc77
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04151286

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