Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 3-Methyl-7-phenyl-1,2,3,4,5,6,7,8-octahydroazonino[5,4-b]indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 1-Methoxy-2-propanol | HCID 7900 | — |
| 반응물 | Lithium | HCID 3028194 | — |
| 반응물 | 2,3,5,6,11,11b-hexahydro-4-methyl-11b-phenyl-1H-indolizino[8,7-b]indolium iodide | HCID 21555017 | — |
| 용매 | Benzene hexane | HCID 110624 | — |
| 생성물 | 3-Methyl-7-phenyl-1,2,3,4,5,6,7,8-octahydroazonino[5,4-b]indole | HCID 21555004 | — |
반응 단계
Then 2,3,5,6,11,11b-hexahydro-4-methyl-11b-phenyl-1H-indolizino[8,7-b]indolium iodide (8.09 g.), 286 mg. lithium, 2.03 g. 1-methoxy-2-propanol and 2 liters liquid ammonia are reacted according to the method of Example I-(a). The white foam isolated from the 1:9 and 1:4 benzene-hexane elutes is crystallized from hexane to provide 4.38 g. base. A 300 mg. portion is crystallized (twice) from hexane thereby yielding 200 mg. of title compound, m.p. 117°-119°C., NMR (CDCl3): δ 2.45 (singlet, 3-methyl), 5.70 (triplet, J 8 cps., 7-hydrogen) ppm.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03943148 |
| 출처 데이터셋 | uspto-grants-1976_03 |
| ORD ID | ord-e61c7fbdf936415a9c9ad3401aff2465 |
| 출처 메모 | uspto-grants-1976_03 |