Sulfuric Acid → chrysanthemic acid d-trans-form

반응식

CC[O:3][C:4]([CH:6]1[C:8]([CH3:10])([CH3:9])[CH:7]1[CH:11]=[C:12]([CH3:14])[CH3:13])=[O:5].S(=O)(=O)(O)O>>[CH3:13][C:12]([CH3:14])=[CH:11][C@H:7]1[C:8]([CH3:9])([CH3:10])[C@@H:6]1[C:4]([OH:5])=[O:3]

참가 물질

반응물 2

HCID 1118Sulfuric Acid

HCID 7334Ethyl chrysanthemate

생성물 1

HCID 16747chrysanthemic acid d-trans-form수율 80%

실험 절차

The water layer was made acidic with sulfuric acid and extracted with toluene (20 g) two times. The toluene layer was washed and distilled under reduced pressure to give trans-chrysanthemic acid (4.2 g; trans-isomer, 80.0 %). B.P. 122° to 130°C/3.3 mmHg.

후처리

extractionextracted with toluene (20 g) two times
washThe toluene layer was washed
distillationdistilled under reduced pressure

출처 및 근거

ORD 기록: ord-c809d282989e4a5fb9afded6da017da3
출처 데이터셋: uspto-grants-1976_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US03943167

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