Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethylene glycol diethyl ether → Difluoromethyl 1,1,2,3,3-pentafluoro-2-propyl ether
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethylene glycol diethyl ether | HCID 8179 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 반응물 | Difluoromethyl 1,3-dichloro-1,1,2,3,3-pentafluoro-2-propyl ether | HCID 86733856 | — |
| 생성물 | Difluoromethyl 1,1,2,3,3-pentafluoro-2-propyl ether | HCID 57127931 | — |
반응 단계
The ether XXVI (213 g, 0.79 mole) at 25°C was stirred as 0.9 M lithium aluminum hydride in diethylene glycol diethyl ether (484 ml, 0.436 mole of Li Al H4) was added dropwise. Then the product was distilled at atmospheric pressure through a cold water condensor into an ice cooled receiver until 157 g of IV was collected. This distillate was fractionally distilled to give IV, b760 68.1°-68.2°C, of 99.7% purity (by gas-liquid chromatography) in 93% of the theoretical yield; density at 23°C was 1.554. The structure of IV was confirmed by proton NMR spectroscopy.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03943256 |
| 출처 데이터셋 | uspto-grants-1976_03 |
| ORD ID | ord-7e033ab4bb6947abb95373d8b210fe2b |
| 출처 메모 | uspto-grants-1976_03 |