Sodium Diethyldithiocarbamate → 2-Amino-5-cyano-6-diethylthiocarbamylthio-1-n-octyl-4-n-octylamino pyridinium chloride

HRID 267735

반응식

HRID 267735 반응식
[Cl-].[NH2:2][C:3]1[CH:8]=[C:7]([NH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:6]([C:18]#[N:19])=[C:5]([Cl:20])[N+:4]=1[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28].[CH2:29]([N:31]([CH2:35][CH3:36])[C:32](=[S:34])[S-:33])[CH3:30].[Na+]>CN(C)C=O>[Cl-:20].[NH2:2][C:3]1[CH:8]=[C:7]([NH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:6]([C:18]#[N:19])=[C:5]([S:34][C:32](=[S:33])[N:31]([CH2:35][CH3:36])[CH2:29][CH3:30])[N+:4]=1[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

참가 물질

4

반응물 2

HCID 533728Sodium DiethyldithiocarbamateHCID 122967422-Amino-6-chloro-5-cyano-1-n-octyl-4-n-octylamino pyridinium chloride

생성물 1

HCID 867331562-Amino-5-cyano-6-diethylthiocarbamylthio-1-n-octyl-4-n-octylamino pyridinium chloride수율 30%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4.5 gms (.01 mole) of 2-amino-6-chloro-5-cyano-1-n-octyl-4-n-octylamino pyridinium chloride (compound 14 - Table 1) was dissolved in dimethylformamide and 2.2 gms (0.01 mole) of sodium diethyldithiocarbamate added and the solution refluxed for 60 minutes. This was then cooled, filtered and the solvent evaporated off. Methanol was added and 1.6 gms (30% yield) of 2-amino-5-cyano-6-diethylthiocarbamylthio-1-n-octyl-4-n-octylamino pyridinium chloride (compound 80 - Table 5) was filtered off and recrystallised from methanol (MPt 124° - 126°C.)

후처리

  1. temperaturethe solution refluxed for 60 minutes
  2. temperatureThis was then cooled
  3. filtrationfiltered
  4. customthe solvent evaporated off
  5. additionMethanol was added

출처 및 근거

ORD 기록
ord-1c92f00fecb54eda8c52435663db76a2
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03944557

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