Potassium Carbonate → 2-Phenyl-2-(2-cyanomethoxyphenoxy)acetonitrile

HRID 267792

반응식

HRID 267792 반응식
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[O:4][CH2:5][C:6]#[N:7].Cl[CH:13]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:14]#[N:15].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:16]1([CH:13]([O:1][C:2]2[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=2[O:4][CH2:5][C:6]#[N:7])[C:14]#[N:15])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

5

반응물 3

HCID 11430Potassium Carbonate2회HCID 123763172-Chloro-2-phenylacetonitrile2회HCID 215539352-(2-Hydroxyphenoxy)acetonitrile

생성물 1

HCID 215539672-Phenyl-2-(2-cyanomethoxyphenoxy)acetonitrile

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 2-(2-hydroxyphenoxy)acetonitrile (14.9 g., 0.1 mole), 2-chloro-2-phenylacetonitrile (15.2 g., 0.1 mole), finely powdered potassium carbonate (13.8 g., 0.1 mole) and 80 ml. of acetone is refluxed 3 hours. The mixture is then treated with 2-chloro-2-phenylacetonitrile (7.6 g., 0.05 mole) and potassium carbonate (6.9 g., 0.5 mole) and refluxed six hours. The mixture is filtered, the solids washed with acetone and the combined filtrate evaporated in vacuo to give an oil. Crystallization of the oil affords 2-phenyl-2-(2-cyanomethoxyphenoxy)acetonitrile.

후처리

  1. temperaturerefluxed six hours
  2. filtrationThe mixture is filtered
  3. washthe solids washed with acetone
  4. customthe combined filtrate evaporated in vacuo
  5. customto give an oil
  6. customCrystallization of the oil

출처 및 근거

ORD 기록
ord-fb7af966e19f41d4a3a52ead66b7bcdc
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03944560

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