Potassium Carbonate → HCID 21553923, 화합물

HRID 267793

반응식

HRID 267793 반응식
[Cl:1][C:2]1[CH:9]=[C:6]([CH:7]=[O:8])[C:5]([OH:10])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl[CH:18]([CH3:21])[C:19]#[N:20]>CC(C)=O>[Cl:1][C:2]1[CH:9]=[C:6]([C:5]([O:10][CH:18]([C:19]#[N:20])[CH3:21])=[CH:4][CH:3]=1)[CH:7]=[O:8]

참가 물질

5

반응물 3

HCID 11430Potassium Carbonate2회HCID 124815-Chloro-salicylaldehydeHCID 5192252-Chloropropionitrile2회

생성물 1

HCID 21553923HCID 21553923, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 5-chlorosalicylaldehyde (78 g., 0.5 mole), finely powdered anhydrous potassium carbonate (103.5 g., 0.75 mole) and acetone (500 ml.) is stirred under reflux and 2-chloropropionitrile (33.6 g., 0.375 mole) is added over a period of about 5 minutes. The mixture is heated under reflux for 1.5 hours and then treated with potassium carbonate (34.5 g., 0.25 mole) followed by more 2-chloropropionitrile (11.2 g., 0.125 mole). Heating and stirring are continued for 31/2 hours, after which the reaction mixture is filtered and the filter-cake washed with acetone. Evaporation of the combined filtrate gives 3-chloro-6-(1-cyanoethoxy)-benzaldehyde which is recrystallized from aqueous methanol.

후처리

  1. temperatureunder reflux
  2. temperatureThe mixture is heated
  3. temperatureunder reflux for 1.5 hours
  4. temperatureHeating
  5. stirringstirring
  6. custom2 hours
  7. filtrationafter which the reaction mixture is filtered
  8. washthe filter-cake washed with acetone
  9. customEvaporation of the combined filtrate

출처 및 근거

ORD 기록
ord-7a6b98e1ac1041ad9fec417b3c3d37b2
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03944560

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