Sulfuric Acid → 5-Fluoro-2-methylindan-1-one

HRID 267829노트

반응식

HRID 267829 반응식
CN(C)[CH2:3][CH:4]([CH3:14])[C:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)=[O:6].S(=O)(=O)(O)O>>[F:13][C:10]1[CH:9]=[C:8]2[C:7](=[CH:12][CH:11]=1)[C:5](=[O:6])[CH:4]([CH3:14])[CH2:3]2

참가 물질

3

반응물 2

HCID 1118Sulfuric AcidHCID 215218873-(Dimethylamino)-1-(4-fluorophenyl)-2-methylpropan-1-one

생성물 1

HCID 30162575-Fluoro-2-methylindan-1-one

반응 조건

온도
90 °C

실험 절차

A mixture of 42 g. (0.20 mole) of 3-dimethylamino-4'-fluoro-2-methylpropiophenone and 100 ml. of concentrated sulfuric acid is warmed to 90°C over one hour and stirred at 90°C for two hours. The reaction is cooled and quenched in ice and the product extracted into toluene. The toluene layer is washed with aqueous sodium hydroxide and water and concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.

후처리

  1. additionA mixture of 42 g
  2. temperatureThe reaction is cooled
  3. customquenched in ice
  4. extractionthe product extracted into toluene
  5. washThe toluene layer is washed with aqueous sodium hydroxide and water
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-50c7515c35324b5c9820dbf91855b0db
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03944600

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