Water → N-(1-Chlorobutan-2-yl)acetamide

HRID 267843

반응식

HRID 267843 반응식
[C:1](#[N:3])[CH3:2].C([O-])([O-])=O.[Ca+2].[OH2:9].[CH2:10]=[CH:11][CH2:12][CH3:13].[Cl:14]Cl>>[Cl:14][CH2:10][CH:11]([NH:3][C:1](=[O:9])[CH3:2])[CH2:12][CH3:13]

참가 물질

6

반응물 5

HCID 962WaterHCID 6342AcetonitrileHCID 78441-ButeneHCID 10112Calcium CarbonateHCID 24526Chlorine2회

생성물 1

HCID 12803237N-(1-Chlorobutan-2-yl)acetamide수율 40.2%

실험 절차

Into a 250 ml. 3-necked flask fitted with a stirrer, dry ice-acetone trap, a gas outlet, and a gas inlet is charged 41.05 g. (1.0 mole) acetonitrile, 25 g. (0.25 mole) CaCO3, 13.5 ml. (0.75 mole) water and 26.8 g. (0.475 mole) 1-butene. The mixture is cooled to -5° to -8° C. and chlorine added over 2 hours maintaining the temperature at below 7° C. until the reaction mixture turns yellow indicating a slight excess of chlorine. The mixture is filtered and the solvents distilled under reduced pressure to yield 28.6 g. of N-[1-(chloromethyl)propyl]acetamide (40.2% yield bases on 1-butene).

후처리

  1. custom3-necked flask fitted with a stirrer, dry ice-acetone trap, a gas outlet, and a gas inlet
  2. additionis charged 41.05 g
  3. temperatureThe mixture is cooled to -5° to -8° C.
  4. temperaturemaintaining the temperature at below 7° C. until the reaction mixture
  5. filtrationThe mixture is filtered
  6. distillationthe solvents distilled under reduced pressure
  7. customto yield 28.6 g

출처 및 근거

ORD 기록
ord-4a668da46eb74b8fa1ee601f6c2dd3df
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03944617

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