Water → N-(1-Chlorobutan-2-yl)acetamide

반응식

[C:1](#[N:3])[CH3:2].[OH2:4].C([O-])([O-])=O.[Na+].[Na+].[CH2:11]=[CH:12][CH2:13][CH3:14].[Cl:15]Cl>>[Cl:15][CH2:11][CH:12]([NH:3][C:1](=[O:4])[CH3:2])[CH2:13][CH3:14]

참가 물질

반응물 5

HCID 962Water

HCID 6342Acetonitrile

HCID 78441-Butene

HCID 10340Sodium Carbonate

HCID 24526Chlorine

생성물 1

HCID 12803237N-(1-Chlorobutan-2-yl)acetamide수율 44%

반응 조건

온도: 25 °C

실험 절차

A 500 ml. 3-necked flask fitted with a stirrer and dry ice-acetone trap is charged with 82.1 g. (2.0 mole) acetonitrile, 27.4 g. (1.52 mole) water, 27 g. (0.25 mole) Na2CO3 and 28.1 g. (0.50 mole) 1-butene and cooled to 0° C. Chlorine (0.50 mole) is added over one-half hour, the reaction temperature reaching a high of 32° C. After stirring for 2 hours at 25° C., the reaction mixture is filtered. The acetonitrile washings of the solid phase and filtrate is combined and the solvents removed by vacuum distillation to leave 33.0 g. of the N-[1-(chloromethyl)propyl]acetamide (44.0% yield based on 1-butene).