Chloroacetyl chloride → HCID 12392970, 화합물
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([CH3:19])([CH3:18])[C:10](=[O:20])[NH:9]2)=[CH:4][CH:3]=1.[Cl:21][CH2:22][C:23](Cl)=[O:24].C(N(CC)CC)C>C(O)(=O)C>[Cl:21][CH2:22][C:23]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([CH3:18])([CH3:19])[C:10](=[O:20])[NH:9]2)=[CH:6][CH:7]=1)=[O:24]참가 물질
5
실험 절차
30.0 g. (0.1125 moles) of 1-(4'-aminophenyl)-1,4-dihydro-4,4-dimethyl-3(2H)-isoquinolinone are reacted in 280 ml. of glacial acetic acid with 14.7 g. (0.13 moles) of chloroacetyl chloride, in the presence of 13.5 g. (0.13 moles) of triethylamine. The reaction conditions are the same as described in Example 1. The crude product is recrystallized from ethanol to yield 25.15 g. of the title compound; m.p.: 218°-219°C.