Dichloromethane → N-methyl-N-(2-chlorocyclooctylthio)-N'-(3,4-dichlorophenyl) urea

반응식

[CH2:1]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[S:10][N:11]([CH3:23])[C:12]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)=[O:13].C(Cl)[Cl:25]>>[CH3:23][N:11]([S:10][CH:1]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[Cl:25])[C:12]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)=[O:13]

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 9266Cyclooctane

HCID 21314661N-chlorothio-N-methyl-N'-(3,4-dichlorophenyl) urea

생성물 1

HCID 54070333N-methyl-N-(2-chlorocyclooctylthio)-N'-(3,4-dichlorophenyl) urea

실험 절차

An 11.0-g (0.1 mol) sample of cyclooctane was added dropwise at 0°C. to a solution of 0.1 mol N-chlorothio-N-methyl-N'-(3,4-dichlorophenyl) urea, prepared by a procedure similar to that of Example 3, in methylene dichloride. After the addition was completed, the reaction mixture was washed successively with water, aqueous sodium bicarbonate solution and water, dried over magnesium sulfate and evaporated to give a solid residue. The solid was recrystallized from isopropyl alcohol and washed with hexane to give 15 g of product, m.p. 90°-91°C. Elemental analysis for C16H21Cl3N2OS showed: %S, calc. 8.1, found 8.2; %Cl, calc. 26.9, found 27.4.