Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isopropanol → Bis(3-diethylaminopropyl) 9-ethylcarbazole-3,6-dicarboxylate dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | 3-Chloropropyl(diethyl)amine | HCID 66918 | — |
| 반응물 | 9-ethyl-9H-carbazole-3,6-dicarboxylic acid | HCID 3797914 | — |
| 촉매 | Benzyltrimethylammonium chloride | HCID 5963 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Bis(3-diethylaminopropyl) 9-ethylcarbazole-3,6-dicarboxylate dihydrochloride | HCID 12331707 | — |
반응 단계
To 250 ml of isopropanol is added 10.0 g (0.035 mole) of 9-ethylcarbazole-3,6-dicarboxylic acid, 21.2 g (0.14 mole) of 3-diethylaminopropylchloride and 0.5 ml of 60% aqueous benzyltrimethylammonium chloride. The solution is heated at reflux for 2 hours with stirring and then allowed to stir overnight at room temperature. Addition of ether to the reaction mixture gives a crystalline product which is recrystallized twice from methanol-acetone to give bis(3-diethylaminopropyl)-9-ethylcarbazole-3,6-dicarboxylate dihydrochloride. M.P. 233°-234°C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03946112 |
| 출처 데이터셋 | uspto-grants-1976_03 |
| ORD ID | ord-c731bbd411ca405b9cb59a8a9db8cc07 |
| 출처 메모 | uspto-grants-1976_03 |