Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Borane → 1,2,3,5,10,11a-Hexahydro-10-methyl-11H-pyrrolo[2,1-c] [1,4] benzodiazepin-11-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Borane | HCID 6331 | — |
| 반응물 | D-Proline | HCID 8988 | — |
| 반응물 | N-Methylisatoic anhydride | HCID 25160 | — |
| 반응물 | 10-methyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione | HCID 9859436 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1,2,3,5,10,11a-Hexahydro-10-methyl-11H-pyrrolo[2,1-c] [1,4] benzodiazepin-11-one | HCID 54501529 | — |
반응 단계
The above compound is obtained when (-)-1,2,3,11 a-tetrahydro-10-methyl-5H-pyrrolo[2,1-c] [1,4] benzodiazepin- 5,11(10H)-dione, melting point 120-122°C. [α]D 25 - 477°, (1.24%, methanol) and (prepared from N-methylisatoic anhydride and D-proline as described in Example 1) is treated with borane in tetrahydrofuran as described in Example 1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03947408 |
| 출처 데이터셋 | uspto-grants-1976_03 |
| ORD ID | ord-ad14593739a846938701f4f516ce75c5 |
| 출처 메모 | uspto-grants-1976_03 |