Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
L-Proline → 10-Ethyl-1,2,3,5,10,11 a-hexahydro-11H-pyrrolo[2,1-c] [1,4] benzodiazepin-11-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | L-Proline | HCID 145742 | — |
| 반응물 | 5H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H)-dione | HCID 301358 | — |
| 반응물 | N-ethylisatoic anhydride | HCID 3249856 | — |
| 반응물 | 10-ethyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione | HCID 17035871 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 10-Ethyl-1,2,3,5,10,11 a-hexahydro-11H-pyrrolo[2,1-c] [1,4] benzodiazepin-11-one | HCID 45095747 | — |
반응 단계
When (+) 10-ethyl-1,2,3,11a-tetrahydro-5 H-pyrrolo[2,1-c] [1,4] benzodiazepin-5,11(10H)-dione, melting point 138° -140°C., (prepared as described above by reacting N-ethylisatoic anhydride with L-proline) is substituted for (+)-1,2,3,11 a-tetrahydro-10-methyl-[5H-pyrrolo [2,1-c] [1,4] benzodiazepin-5,11 -(10H)-dione in the procedure of Example 1, the above compound is obtained. The hydrochloride salt melts at 233°-235°C., [α]D 25 + 415° (0.9% in methanol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03947408 |
| 출처 데이터셋 | uspto-grants-1976_03 |
| ORD ID | ord-7c3b250014054028ae1647fcb20c6b75 |
| 출처 메모 | uspto-grants-1976_03 |