Methyl Ethyl Ketone → 3-[4-(3-Di-n-butylaminopropoxy)benzoyl]-2-phenylbenzofuran

HRID 268343

반응식

HRID 268343 반응식
[OH:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([C:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[O:10][C:9]=2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:7])=[CH:4][CH:3]=1.[CH2:25]([N:29]([CH2:34][CH2:35][CH2:36][CH3:37])[CH2:30][CH2:31][CH2:32]Cl)[CH2:26][CH2:27][CH3:28].C(=O)([O-])[O-].[K+].[K+].CC(=O)CC>CCOCC.O>[CH2:34]([N:29]([CH2:25][CH2:26][CH2:27][CH3:28])[CH2:30][CH2:31][CH2:32][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[O:10][C:9]=2[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:7])=[CH:23][CH:24]=1)[CH2:35][CH2:36][CH3:37]

참가 물질

7

반응물 4

HCID 6569Methyl Ethyl KetoneHCID 11430Potassium CarbonateHCID 96084N-(3-Chloropropyl)dibutylamineHCID 13264991(4-Hydroxyphenyl)(2-phenyl-1-benzofuran-3-yl)methanone

생성물 1

HCID 214353183-[4-(3-Di-n-butylaminopropoxy)benzoyl]-2-phenylbenzofuran

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

A mixture of 2.0 g. (6.4 mmol.) of 3-(4-hydroxybenzoyl)-2-phenylbenzofuran, 1.3 g. (6.4 mmol.) of 3-di-n-butylaminopropyl chloride and 4.0 g. (0.04 mol.) of anhydrous potassium carbonate in 20 ml. of dry 2-butanone is refluxed for 18 hours. The reaction is cooled, water and ether are added and the layers are separated. The organic phase is extracted with 10% aqueous sodium hydroxide and the aqueous layers are combined and extracted again with water. The combined ether extracts are concentrated under reduced pressure to give the title compound.

후처리

  1. additionA mixture of 2.0 g
  2. temperatureThe reaction is cooled
  3. customthe layers are separated
  4. extractionThe organic phase is extracted with 10% aqueous sodium hydroxide
  5. extractionextracted again with water
  6. concentrationThe combined ether extracts are concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-53826219a097465b97c761cc54cc0b80
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03947470

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