Acetyl chloride → Phenyl acetate

HRID 268510

반응식

HRID 268510 반응식
[O-:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8](Cl)(=[O:10])[CH3:9]>CCOCC>[C:8]([O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)(=[O:10])[CH3:9]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 119047Phenolate

생성물 1

HCID 31229Phenyl acetate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A vigorously stirred suspension of thallous phenoxide (5 g., 0.017 m.) in anhydrous ether (15 ml.) is treated dropwise with freshly distilled acetyl chloride (1.33 g., 0.017 m.) in anhydrous ether (3 ml.) over 5 mins. at such a rate that the exothermic reaction is controlled. The mixture is then stirred for 1 hour at room temperature, the precipitated thallous chloride removed by filtration through Celite and the solvent evaporated under vacuum. The residual colorless oil is distilled to give phenyl acetate, 2.27 g., 98%, b.p. 110°/58 mm.

후처리

  1. customat such a rate that the exothermic reaction
  2. customthe precipitated thallous chloride
  3. customremoved by filtration through Celite
  4. customthe solvent evaporated under vacuum
  5. distillationThe residual colorless oil is distilled

출처 및 근거

ORD 기록
ord-52748cb56aef414f9320e2f419e3bd4b
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03947488

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