Hydrazine → 3-Amino-6-chloro-3,4-dihydro-4-phenylquinazolin-4-ol
반응식
[C:1]([C:9]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:10]=1[NH:11][CH:12]=O)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:19][NH2:20]>C(O)C>[NH2:19][N:20]1[C:1]([OH:8])([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:9]2[C:10](=[CH:14][CH:15]=[C:16]([Cl:18])[CH:17]=2)[N:11]=[CH:12]1참가 물질
4
실험 절차
A mixture of 0.1 mole of 2'-benzoyl-4'-chloroformanilide and 0.15 mole of hydrazine are stirred at room temperature in ethanol. Stirring is continued for 20 hours. The reaction mixture is chilled, and the precipitate filtered. The solid is washed and recrystallized from dimethylformamide to give 3-amino-6-chloro-3,4-dihydro-4-hydroxy-4-phenylquinazoline.
후처리
- temperatureThe reaction mixture is chilled
- filtrationthe precipitate filtered
- washThe solid is washed
- customrecrystallized from dimethylformamide
출처 및 근거
- ORD 기록
- ord-66b31b2810e14ea4b091bff004316bca
- 출처 데이터셋
- uspto-grants-1976_03
- 특허 번호
- US03947466
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