2-Benzyl-1,3-thiazole-4-carboxylic acid → (2-Benzylthiazol-4-yl)methanol

HRID 26864노트

반응식

HRID 26864 반응식
[CH2:1]([C:8]1[S:9][CH:10]=[C:11]([C:13](O)=[O:14])[N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:1]([C:8]1[S:9][CH:10]=[C:11]([CH2:13][OH:14])[N:12]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 14915702-Benzyl-1,3-thiazole-4-carboxylic acidHCID 21226445Aluminium lithium hydride

생성물 1

HCID 13102618(2-Benzylthiazol-4-yl)methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2-Benzyl-4-thiazolecarboxylic acid is converted to the methyl ester and the ester is reduced with lithium aluminium hydride in tetrahydrofuran to give 2-benzyl-4-hydroxymethylthiazole. Using this compound as the starting material in the procedure of Example 1 gives N-methyl-N'-[2-((2-benzyl-4-thiazolyl)methylthio)ethyl]thiourea.

출처 및 근거

ORD 기록
ord-282aad152f214ccfbd5444b07794054f
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04151288

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