Potassium Carbonate → Tert-butyl-7-[(2-phenyl-5-methyl-1,3-oxazol-4-yl)methoxy]chromane-3-carboxylate

HRID 268699노트

반응식

HRID 268699 반응식
Cl[CH2:2][C:3]1[N:4]=[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[O:6][C:7]=1[CH3:8].C(=O)([O-])[O-].[K+].[K+].[OH:21][C:22]1[CH:31]=[C:30]2[C:25]([CH2:26][CH:27]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[CH2:28][O:29]2)=[CH:24][CH:23]=1>O>[C:35]([O:34][C:32]([CH:27]1[CH2:26][C:25]2[C:30](=[CH:31][C:22]([O:21][CH2:2][C:3]3[N:4]=[C:5]([C:9]4[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=4)[O:6][C:7]=3[CH3:8])=[CH:23][CH:24]=2)[O:29][CH2:28]1)=[O:33])([CH3:38])([CH3:36])[CH3:37]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 97942894-(Chloromethyl)-5-methyl-2-phenyl-1,3-oxazoleHCID 59832111Tert-butyl 7-hydroxychromane-3-carboxylate

생성물 1

HCID 69279834Tert-butyl-7-[(2-phenyl-5-methyl-1,3-oxazol-4-yl)methoxy]chromane-3-carboxylate수율 71.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a stirred solution of 4-(chloromethyl)-5-methyl-2-phenyl-1,3-oxazole (103.5 mg, 0.5 mmol) and potassium carbonate (138.4 mg, 1 mmol), tert-butyl 7-hydroxychromane-3-carboxylate (125 mg, 0.5 mmol) was added and the reaction mixture was stirred at room temperature for 48 hrs. Water (50 ml) was added and the precipitated product was extracted with 25 ml of diethyl ether. Ether layer was washed with water (25 ml) twice and dried. On evaporation of solvent, the product was obtained as pale yellow gum (150 mg, 36%).

후처리

  1. extractionthe precipitated product was extracted with 25 ml of diethyl ether
  2. washEther layer was washed with water (25 ml) twice
  3. customdried
  4. customOn evaporation of solvent

출처 및 근거

ORD 기록
ord-8312fd09f0f741928d9a29f2500a4296
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446127B2

반응 노트

불러오는 중…