Potassium Carbonate → Tert-butyl-7-[(2-(4-bromophenyl)-5-methyl-1,3-oxazol-4-yl)methoxy]chromane-3-carboxylate

HRID 268701노트

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HRID 268701 반응식
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH:7]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][O:9]2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Br:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]2[O:33][C:34]([CH3:39])=[C:35]([CH2:37]Cl)[N:36]=2)=[CH:28][CH:27]=1>O>[C:15]([O:14][C:12]([CH:7]1[CH2:6][C:5]2[C:10](=[CH:11][C:2]([O:1][CH2:37][C:35]3[N:36]=[C:32]([C:29]4[CH:30]=[CH:31][C:26]([Br:25])=[CH:27][CH:28]=4)[O:33][C:34]=3[CH3:39])=[CH:3][CH:4]=2)[O:9][CH2:8]1)=[O:13])([CH3:18])([CH3:17])[CH3:16]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 109571082-(4-Bromophenyl)-4-(chloromethyl)-5-methyloxazoleHCID 59832111Tert-butyl 7-hydroxychromane-3-carboxylate

생성물 1

HCID 69279608Tert-butyl-7-[(2-(4-bromophenyl)-5-methyl-1,3-oxazol-4-yl)methoxy]chromane-3-carboxylate수율 77.4%

시약·촉매·용매 1

HCID 962Water용매

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온도
60 °C

실험 절차

To a stirred suspension of tert-butyl 7-hydroxychromane-3-carboxylate (1.1 g, 4.4 mmol) and potassium carbonate (1.1 g, 8 mmol), 2-(4-bromophenyl)-4-(chloromethyl)-5-methyl-1,3-oxazole (1.14 g, 4 mmol) was added and the reaction mixture was stirred at 60° C. for overnight. After the completion of the reaction, water (40 ml) was added and the precipitated product was extracted with ethylacetate (60 ml). The organic layer was washed with 50 ml of water twice and dried. The dried solution was evaporated to give the product as brown solid (1.55 g, 77.4%).

후처리

  1. additionwas added
  2. additionwas added
  3. extractionthe precipitated product was extracted with ethylacetate (60 ml)
  4. washThe organic layer was washed with 50 ml of water twice
  5. customdried
  6. customThe dried solution was evaporated

출처 및 근거

ORD 기록
ord-a3d340ab3ed64250b45df0e7cea8363c
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446127B2

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