4-[(1-Cyclobutyl-4-piperidinyl)oxy]benzoic acid hydrochloride → 4-[(1-Cyclobutyl-4-piperidinyl)oxy]benzoyl chloride hydrochloride
반응식
[ClH:1].[CH:2]1([N:6]2[CH2:11][CH2:10][CH:9]([O:12][C:13]3[CH:21]=[CH:20][C:16]([C:17](O)=[O:18])=[CH:15][CH:14]=3)[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3]1>S(Cl)(Cl)=O>[ClH:1].[CH:2]1([N:6]2[CH2:11][CH2:10][CH:9]([O:12][C:13]3[CH:21]=[CH:20][C:16]([C:17]([Cl:1])=[O:18])=[CH:15][CH:14]=3)[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3]1참가 물질
3
실험 절차
4-[(1-Cyclobutyl-4-piperidinyl)oxy]benzoic acid hydrochloride (D24) (0.20 g) was dissolved in thionyl chloride (10 ml) and heated under reflux for 1.5 h. The thionyl chloride was removed by evaporation and the residue evaporated from DCM (3×10 ml) to give the title compound (D25) (0.21 g).
후처리
- temperatureheated
- temperatureunder reflux for 1.5 h
- customThe thionyl chloride was removed by evaporation
- customthe residue evaporated from DCM (3×10 ml)
출처 및 근거
- ORD 기록
- ord-8b8a52be8c1d4fc3b57053cbe9915615
- 출처 데이터셋
- uspto-grants-2008_11
- 특허 번호
- US07446103B2
반응 노트
불러오는 중…