2-Chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoic acid hydrochloride → 2-Chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoyl chloride hydrochloride

HRID 268727노트

반응식

HRID 268727 반응식
[ClH:1].[Cl:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][N:16]([CH:19]3[CH2:22][CH2:21][CH2:20]3)[CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5](O)=[O:6]>S(Cl)(Cl)=O>[ClH:2].[Cl:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][N:16]([CH:19]3[CH2:22][CH2:21][CH2:20]3)[CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5]([Cl:1])=[O:6]

참가 물질

3

반응물 1

HCID 689660102-Chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoic acid hydrochloride

생성물 1

HCID 179862522-Chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoyl chloride hydrochloride수율 199.4%

시약·촉매·용매 1

HCID 24386Thionyl Chloride용매

실험 절차

2-Chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoic acid hydrochloride (D35) (0.20 g) was dissolved in thionyl chloride (10 ml) and heated under reflux for 1.5 h. The thionyl chloride was removed by evaporation and the residue evaporated from DCM (3×10 ml) to give the title compound (D36) (0.21 g).

후처리

  1. temperatureheated
  2. temperatureunder reflux for 1.5 h
  3. customThe thionyl chloride was removed by evaporation
  4. customthe residue evaporated from DCM (3×10 ml)

출처 및 근거

ORD 기록
ord-c5f30595da3345ba8bea3dcbfe2d3aee
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446103B2

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