6-Bromo-1-methyl-1H-indole → 3-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester

HRID 268829노트

반응식

HRID 268829 반응식
Br[C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][N:8]2[CH3:11])=[CH:4][CH:3]=1.[CH2:12]([O:14][C:15](=[O:35])[CH:16]=[C:17](C1C=CC=C2C=1C(C#N)=CN2)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:13]>>[CH2:12]([O:14][C:15](=[O:35])[CH:16]=[C:17]([C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][N:8]2[CH3:11])=[CH:4][CH:3]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:13]

참가 물질

3

반응물 2

HCID 155468546-Bromo-1-methyl-1H-indoleHCID 673553223-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester

생성물 1

HCID 673550473-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester수율 78%

실험 절차

3-(1-Methyl-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester CXLIII (78% yield) was prepared from 6-bromo-1-methyl-1H-indole using the procedure described above for preparation of 3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester LVIII (Example 14).

출처 및 근거

ORD 기록
ord-3466369667924574b3d20b0e7873118d
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446118B2

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