6-Bromo-1H-indole-3-carbonitrile → 3-(3-Cyano-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester

HRID 268835노트

반응식

HRID 268835 반응식
Br[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]#[N:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[CH2:13]([O:15][C:16](=[O:36])[CH:17]=[C:18](C1C=C(OC)C=C2C=1C=CN2)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH3:14]>>[CH2:13]([O:15][C:16](=[O:36])[CH:17]=[C:18]([C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]#[N:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH3:14]

참가 물질

3

반응물 2

HCID 114700676-Bromo-1H-indole-3-carbonitrileHCID 673560903-(6-Methoxy-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester

생성물 1

HCID 673557733-(3-Cyano-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester

실험 절차

3-(3-Cyano-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester CLII was prepared from 6-bromo-1H-indole-3-carbonitrile using the procedure described above for preparation of 3-(6-Methoxy-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester CXVI (Example 25).

출처 및 근거

ORD 기록
ord-f2333a114fa8483ebcb9ef84295fbfc0
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446118B2

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