2-Aminothiazole → N-benzoyl-N'-[3-(2-thiazolylamino)propyl]thiourea

반응식

[NH2:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[S:7][CH:8]=[CH:9][N:10]=1.NC1SC=CN=1.[C:17]([N:25]=[C:26]=[S:27])(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:17]([NH:25][C:26]([NH:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[S:7][CH:8]=[CH:9][N:10]=1)=[S:27])(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

반응물 3

HCID 21552-Aminothiazole

HCID 68284Benzoyl isothiocyanate

HCID 205580022-(3-Aminopropylamino)thiazole

생성물 1

HCID 20557898N-benzoyl-N'-[3-(2-thiazolylamino)propyl]thiourea

실험 절차

By the procedure of Example 46, reacting 2-(3-aminopropylamino)thiazole (prepared from 2-aminothiazole by the method of Example 53) with benzoyl isothiocyanate gives N-benzoyl-N'-[3-(2-thiazolylamino)propyl]thiourea. Removing the benzoyl group by the procedure of Example 46 gives N-[3-(2-thiazolylamino)propyl)thiourea.

출처 및 근거

ORD 기록: ord-3b8d45bd12844b23b5a9aaffeac00e46
출처 데이터셋: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04151288

반응 노트

불러오는 중…