Triethylamine → 2-Chloro-1,3-thiazole-5-sulfonamide

반응식

[Cl:1][C:2]1[S:3][C:4]([S:7](Cl)(=[O:9])=[O:8])=[CH:5][N:6]=1.CC[N:13](CC)CC>>[Cl:1][C:2]1[S:3][C:4]([S:7]([NH2:13])(=[O:9])=[O:8])=[CH:5][N:6]=1

참가 물질

반응물 2

HCID 8471Triethylamine

HCID 162289432-Chloro-1,3-thiazole-5-sulfonyl chloride

생성물 1

HCID 220195182-Chloro-1,3-thiazole-5-sulfonamide수율 61%

실험 절차

Prepared by general procedure III from 2-Chloro-thiazole-5-sulfonyl chloride (1.1 g, 5 mmol) and NH40H (0.42 mL, 6 mmol) with Et3N (0.77 mL, 6 mmol to give the title compound as a light-brown solid (610 mg, 61%). MS (ISN) 197[(M−H)−].

출처 및 근거

ORD 기록: ord-bc99af307e574dab9ca36fa1ffcdde08
출처 데이터셋: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07446113B2

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