Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrogen iodide → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrogen iodide | HCID 24841 | — |
| 반응물 | Sodium Bisulfite | HCID 23665763 | — |
| 반응물 | 3-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester | HCID 53834251 | — |
| 반응물 | 3-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid | HCID 54010068 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 3-(2',4'-Difluoro-4-biphenylyl)butyric acid | HCID 21322540 | — |
반응 단계
1 g. of 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester, or the corresponding free hydroxy acid or 3-(2',4'-difluoro-4-biphenylyl)-2-butenoic acid, is heated with 2 ml. of 67% hydriodic acid and 4 ml. of acetic acid at 150° for 1 hour and the mixture is poured onto ice and decolorized with NaHSO3 solution. After the customary work up, 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°, is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04151302 |
| 출처 데이터셋 | uspto-grants-1979_04 |
| ORD ID | ord-33adb9ea9eaf4650a352ffb45849f2e3 |
| 출처 메모 | uspto-grants-1979_04 |