Sulfuric Acid → 3-(3',4'-Dichloro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester

HRID 26909노트

반응식

HRID 26909 반응식
Br[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[C:8]([C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([Cl:24])[CH:18]=2)=[CH:13][CH:12]=1)(=[O:10])[CH3:9].S(=O)(=O)(O)O>[Zn].C1C=CC=CC=1>[CH2:6]([O:5][C:3](=[O:4])[CH2:2][C:8]([C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([Cl:24])[CH:18]=2)=[CH:13][CH:12]=1)([OH:10])[CH3:9])[CH3:7]

참가 물질

6

반응물 3

HCID 1118Sulfuric AcidHCID 7748Ethyl bromoacetateHCID 167688151-[4-(3,4-Dichlorophenyl)phenyl]ethan-1-one

생성물 1

HCID 544122843-(3',4'-Dichloro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 241Benzene용매

실험 절차

A mixture of 20 g. of ethyl bromoacetate, 26.5 g. of 4-acetyl-3',4'-dichlorobiphenyl and 8 g. of zinc foil is added to 100 ml. of benzene and the mixture is stirred and heated under reflux for one hour. It is cooled and dilute sulfuric acid is added to decompose the alcoholate obtained. The organic phase is separated off and, after the customary work up, 3-(3',4'-dichloro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester is obtained.

후처리

  1. additionA mixture of 20 g
  2. temperatureheated
  3. temperatureunder reflux for one hour
  4. temperatureIt is cooled
  5. customobtained
  6. customThe organic phase is separated off

출처 및 근거

ORD 기록
ord-4e1f0da971e1426899736fcb4ac4bc66
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04151302

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