Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → 3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | 4-Hydroxy-2-Butanone | HCID 111509 | — |
| 반응물 | Magnesium | HCID 5462224 | — |
| 반응물 | 1,1'-Biphenyl, 4'-bromo-2,4-difluoro- | HCID 21322611 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol | HCID 21322562 | — |
반응 단계
0.44 g. of 1 -hydroxy-3-butanone in 40 ml. of ether is added dropwise, at 20° to stirred Grignard solution obtained from 2.69 g. of 4-bromo-2',4'-difluorobiphenyl and 0.24 g. of magnesium in 100 ml. of ether. The mixture is stirred for two hours more and the resulting alcoholate is decomposed with dilute sulfuric acid. The ether phase is worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol, m.p. 82°-84°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04151302 |
| 출처 데이터셋 | uspto-grants-1979_04 |
| ORD ID | ord-d3e09d4998144f26af463aa41940b803 |
| 출처 메모 | uspto-grants-1979_04 |